PHENACETIN NEPHROPATHY

Four patients who had ingested large amounts of phenacetin-salicylate medications were studied during a 12-month period. Renal failure had progressed slowly over a number of years. All patients took the drug because of psychogenic headache. Considerable skill was required to elicit the history of dr...

Full description

Saved in:
Bibliographic Details
Published inCanadian Medical Association journal Vol. 92; no. 2; pp. 55 - 59
Main Authors RAMSAY, A G, WHITE, D F
Format Journal Article
LanguageEnglish
Published Canada 09.01.1965
Subjects
Acidosis
Animals
Aspirin
Bacteriuria
Biological Transport
Caffeine
Codeine
Dogs
Drug Therapy
Headache
Humans
Kidney Diseases
Kidney Papillary Necrosis
Kidney Tubules
Metabolism
Neoplasm Recurrence, Local
Neoplasms
Original
Phenacetin
Polyuria
Proteinuria
Pyuria
Salicylates
Sodium
Toxicology
SODIUM
DRUG THERAPY
ACIDOSIS
CAFFEINE
KIDNEY DISEASES
POLYURIA
SALICYLATES
PYURIA
TOXICOLOGIC REPORT
KIDNEY TUBULES
NEOPLASM RECURRENCE, LOCAL
PHENACETIN
METABOLISM
HEADACHE
BIOLOGICAL TRANSPORT
KIDNEY PAPILLARY NECROSIS
CODEINE
Online AccessGet full text

Cover

More Information
Summary:Four patients who had ingested large amounts of phenacetin-salicylate medications were studied during a 12-month period. Renal failure had progressed slowly over a number of years. All patients took the drug because of psychogenic headache. Considerable skill was required to elicit the history of drug habituation. The major features of the nephropathy were multiple episodes of metabolic acidosis, minimal proteinuria, pyuria but no bacteriuria, and polyuria and polydipsia early in the course of drug ingestion. Papillary necrosis was not a prominent clinical feature of this series. Discontinuation of drug ingestion by one patient was associated with recovery of a considerable degree of renal function. Preliminary experimental evidence obtained in the dog suggests that salicylate impaired the efficiency of the counter-current multiplier by decreasing sodium transport in the ascending limb of Henle, and decreased the permeability to water of the distal convoluted and collecting tubule; phenacetin had no such effect.
ISSN:0008-4409