A second-generation YAC contig map of human chromosome 3

A map of human chromosome 3 which integrates both physical and genetic data has been developed from the fusion of two large collections of markers and corresponding yeast artificial chromosome (YAC) clones. The map contains 972 megabase-sized YACs identified with 593 primary markers, of which 162 ar...

Full description

Saved in:
Bibliographic Details
Published inNature (London) Vol. 377; no. 6547 Suppl; p. 299
Main Authors Gemmill, R M, Chumakov, I, Scott, P, Waggoner, B, Rigault, P, Cypser, J, Chen, Q, Weissenbach, J, Gardiner, K, Wang, H
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 28.09.1995
Subjects
Chromosome Mapping
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 3
Clones
Databases, Factual
Deoxyribonucleic acid
DNA
Genes
Genetic Markers
Genetics
Humans
Molecular biology
Sequence Tagged Sites
Software
Yeast
Yeasts
Online AccessGet full text

Cover

More Information
Summary:A map of human chromosome 3 which integrates both physical and genetic data has been developed from the fusion of two large collections of markers and corresponding yeast artificial chromosome (YAC) clones. The map contains 972 megabase-sized YACs identified with 593 primary markers, of which 162 are highly polymorphic sequence-tagged sites (STSs) and form a closely spaced genetic linkage map; the remaining markers are hybridization-based. Chromosome 3 is now represented by 24 large YAC contigs whose order and orientation is largely known. The map generated by fusion of these hybridization- and STS-based datasets covers about 80% (over 160 megabases) of the chromosome and will provide the foundation necessary for rapid development of a detailed genetic understanding for this large autosome.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0028-0836
1476-4687