LABORATORY TESTS ON THE EFFECTIVENESS OF ORAL VACCINATION OF YOUNG CHILDREN AGAINST TYPHOID AND PARATYPHOID A AND B

In Romania, pre-school children are excluded from subcutaneous inoculation with typhoid and paratyphoid A and B vaccine. The authors have therefore investigated the possibility of giving them an oral vaccine. Laboratory tests were carried out on 30 children from 3 to 7 years of age. Samples of blood...

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Published inBulletin of the World Health Organization Vol. 32; no. 1; pp. 37 - 45
Main Authors VLADOIANU, I R, DIMACHE, G, ANTOHI, S, VLADOIANU, C, ZARMA, O
Format Journal Article
LanguageEnglish
Published Switzerland 1965
Subjects
Administration, Oral
Animals
Chick Embryo
Child
Humans
Mice
Old Medline
Paratyphoid Fever
Romania
Serology
Typhoid Fever
Typhoid-Paratyphoid Vaccines
Vaccination
Romania
CHICK EMBRYO
TYPHOID-PARATYPHOID VACCINES
VACCINATION
RUMANIA
MICE
CHILD
SEROLOGY
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Summary:In Romania, pre-school children are excluded from subcutaneous inoculation with typhoid and paratyphoid A and B vaccine. The authors have therefore investigated the possibility of giving them an oral vaccine. Laboratory tests were carried out on 30 children from 3 to 7 years of age. Samples of blood serum were collected before and after vaccination and subsequently tested for (1) seroprotection in chick embryos, (2) seroprotection in white mice, (3) titration of the agglutinating antibodies, and (4) electrophoretic pattern.The results obtained showed that the oral administration of the vaccine can, under the conditions used in the test, afford a considerable degree of protection to young children.
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ISSN:0042-9686