Isotopically labeled analogues for drug quantitation

Liu et al look at how to overcome problems associated with using isotopically labeled analogues as internal standards for the quantitation of drugs in media. If analytical instrumentation and specimen pretreatment technologies are the "hardware" aspects of the analytical sciences, then ILA...

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Bibliographic Details
Published inAnalytical chemistry (Washington) Vol. 74; no. 23; pp. 618A - 626A
Main Authors LIU, Ray H, LIN, D.-L, CHANG, Wei-Tung, CHIAREIY LIU, TSAY, Wen-Ing, LI, Jih-Heng, KUO, Tsung-Li
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 01.12.2002
Subjects
Analysis
Analytical chemistry
Biological and medical sciences
Chemistry
Chromatographic methods and physical methods associated with chromatography
Drug Monitoring - methods
Drug Monitoring - standards
Drugs
Exact sciences and technology
Gas chromatographic methods
General pharmacology
Isotopes
Isotopes - standards
Mass Spectrometry
Medical sciences
Pharmaceutical Preparations - analysis
Pharmacology. Drug treatments
Reference Standards
Spectrometric and optical methods
Drug
Gas chromatography
Biochemical analysis
Isotope labelling
Metabolite
Analog
Internal standard
Biological medium
Mass spectrometry
Quantitative analysis
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Summary:Liu et al look at how to overcome problems associated with using isotopically labeled analogues as internal standards for the quantitation of drugs in media. If analytical instrumentation and specimen pretreatment technologies are the "hardware" aspects of the analytical sciences, then ILAs may be considered the complementary "software" component that is needed for advanced hardware to reach its full potential in quantitation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0003-2700
1520-6882
DOI:10.1021/ac022161m