Glycemia and immune responses

The intensity of experimental and clinical immune responses was correlated with the degree of glycemia of the reacting subject. Hyperglycemias resulting from overdosage with sugars, cortisol, adrenaline, or from diabetes inhibit the anaphylactoid reactions; anaphylaxis, and the tuberculin reaction;...

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Bibliographic Details
Published inCanadian Medical Association journal Vol. 88; no. 15; pp. 806 - 811
Main Author ADAMKIEWICZ, V W
Format Journal Article
LanguageEnglish
Published Canada 13.04.1963
Subjects
Anaphylaxis
Antigen-Antibody Reactions
Blood Glucose
Diabetes Mellitus
Humans
Hyperglycemia
Hypersensitivity
Hypoglycemia
Insulin
Old Medline
Special
ANAPHYLAXIS
ANTIGEN-ANTIBODY REACTIONS
BLOOD SUGAR
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Summary:The intensity of experimental and clinical immune responses was correlated with the degree of glycemia of the reacting subject. Hyperglycemias resulting from overdosage with sugars, cortisol, adrenaline, or from diabetes inhibit the anaphylactoid reactions; anaphylaxis, and the tuberculin reaction; but potentiate infections. Hypoglycemias resulting from fasting, insulin and adrenalectomy potentiate the anaphylactoid reactions, anaphylaxis, and the tuberculin reaction; but inhibit infections. The hypothesis is proposed that hyperglycemia inhibits certain antigen-antibody combinations; this results in an inhibition of hypersensitivity, but an aggravation of infection.
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ISSN:0008-4409