A COMPARISON OF THE ORAL AND INTRAVENOUS GLUCOSE TOLERANCE TESTS IN NON-DIABETIC, POSSIBLE DIABETIC AND DIABETIC SUBJECTS

Results of standard three-hour oral glucose tolerance tests (OGTT) and intravenous glucose tolerance tests (IVGTT), performed on the same subjects, were compared in an attempt to determine their value in the diagnosis of borderline diabetes. A total of 83 such tests were carried out on 81 subjects....

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Published inCanadian Medical Association journal Vol. 91; no. 26; pp. 1350 - 1353
Main Authors NADON, G W, LITTLE, J A, HALL, W E, O'SULLIVAN, M O
Format Journal Article
LanguageEnglish
Published Canada 26.12.1964
Subjects
Blood Glucose
Diabetes Mellitus
Female
Glucose
Glucose Intolerance
Glucose Tolerance Test
Humans
Old Medline
Original
Thrombophlebitis
United States
United States
DIABETES MELLITUS
GLUCOSE TOLERANCE TEST
THROMBOPHLEBITIS
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Summary:Results of standard three-hour oral glucose tolerance tests (OGTT) and intravenous glucose tolerance tests (IVGTT), performed on the same subjects, were compared in an attempt to determine their value in the diagnosis of borderline diabetes. A total of 83 such tests were carried out on 81 subjects. Applying the U.S. Public Health Service point count method to the results of the OGTT test, there were 38 normals, 23 possible diabetics and 22 diabetics. A constant (K) was calculated from the glucose disappearance rate in the IVGTT curves.K disagreed with the OGTT classification to a significant extent, especially in the possible diabetic and non-diabetic groups. Also, the correlation coefficients between K and the OGTT values were not impressive. This does not mean that one test is superior to the other, only that the accuracy of either test in diagnosing early diabetes is doubtful.Technically, the IVGTT was more difficult and time-consuming, and six of the 81 subjects suffered from thrombophlebitis at the site of glucose injection.
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ISSN:0008-4409