Effect of hyperoxia and hypoxia on subcutaneous tissue gases and pH : An experimental study in pigs

The effect of different fractions of inspired oxygen on subcutaneous oxygen tension, carbon dioxide tension and pH in relation to arterial and mixed venous blood gases and pH and hemodynamic variables was evaluated in 13 domestic pigs. Subcutaneous, arterial and mixed venous oxygen tensions were clo...

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Published inEuropean surgical research Vol. 31; no. 4; pp. 333 - 339
Main Authors MELLSTRÖM, A, HARTMANN, M, JEDLINSKA, B, JÖNSSON, K
Format Journal Article
LanguageEnglish
Published Freiburg Karger 01.07.1999
Basel S. Karger AG
Paris
Subjects
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Carbon Dioxide - metabolism
Dermis - blood supply
Dermis - metabolism
Disease Models, Animal
Emergency and intensive postoperative care (general aspects). Pathophysiology of surgery
Hemodynamics
Hydrogen-Ion Concentration
Hyperoxia - metabolism
Hypoxia - metabolism
Intensive care medicine
Medical sciences
Miscellaneous
Oxygen - metabolism
Oxygen Consumption
Space life sciences
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Swine
Animal model
Oxygen
Pathogenesis
Use
Carbon dioxide
Medical screening
Metabolism
Pig
Vertebrata
Mammalia
Animal
Hyperoxia
pH
Hypoxia
Tension
Artiodactyla
Oxygenation
Subcutaneous tissue
Ungulata
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Summary:The effect of different fractions of inspired oxygen on subcutaneous oxygen tension, carbon dioxide tension and pH in relation to arterial and mixed venous blood gases and pH and hemodynamic variables was evaluated in 13 domestic pigs. Subcutaneous, arterial and mixed venous oxygen tensions were closely correlated (r = 0.94). A minor significant increase in subcutaneous carbon dioxide tension was noted during hyperoxia (p < 0.05). A major increase (33%) was noted during the last step of hypoxia, when arterial and mixed venous carbon dioxide tensions increased only 12 and 17%, respectively. A minor decrease in subcutaneous pH was noted during hyperoxia (p < 0.05) and a major decrease during hypoxia (p < 0.05). Measurements of subcutaneous tissue gases and pH are indicators of oxygen utilization during hyper- and hypoxia.
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ISSN:0014-312X
1421-9921
DOI:10.1159/000008710