Evaluation of regional liver function by gadolinium-EOB-DTPa-enhanced MR imaging

• Published in: Digestive diseases and sciences Vol. 44; no. 7; pp. 1330 - 1337
• Main Authors: SHIMIZU, J, DONO, K, KATO, N, MIYAZAWA, T, NAKAMURA, H, MONDEN, M, GOTOH, M, HASUIKE, Y, KIM, T, MURAKAMI, T, SAKON, M, UMESHITA, K, NAGANO, H, NAKAMORI, S
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.07.1999; Springer Nature B.V
• Subjects: Animals; Biological and medical sciences; Contrast Media; Digestion. Liver. Biliary tract. Spleen. Pancreas; Gadolinium DTPA; Image Enhancement; Investigative techniques, diagnostic techniques (general aspects); Ischemia - pathology; Ischemia - physiopathology; Liver - blood supply; Liver - pathology; Liver - physiopathology; Liver Function Tests; Magnetic Resonance Imaging; Male; Medical sciences; Radionuclide investigations; Rats; Rats, Wistar; Regional Blood Flow - physiology; Reperfusion Injury - pathology; Reperfusion Injury - physiopathology; Evaluation; Radiodiagnosis; Rat; Liver; Rodentia; Cardiovascular disease; Hepatic disease; Gadolinium; Regional; Experimental study; Nuclear magnetic resonance imaging; Blood flow; Vascular disease; Enhancement mode; Vertebrata; Mammalia; Reperfusion; Ischemia; Animal; Running; Digestive diseases; Medical imagery; Molecular biology; ATP
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1023/A:1026679113772

We evaluated the role of magnetic resonance (MR) imaging with gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA), in estimating regional liver function in a rat ischemia-reperfusion model. Ischemic liver damage was induced in the right lobe by vascular clamping for 0 (sham), 30 (I-30), 60 (I-60), and 90 min (I-90 group). The ischemic lobes in the I-60 and I-90 groups was clearly visualized as a high intensity area in the T1 images at late phase of Gd-EOB-DTPA enhancement, Moreover, the T1/2 of signal intensity in ischemic lobes significantly correlated with the duration of vascular clamping. We also observed significant correlation between T1/2 and ATP concentration in the liver tissue (r = -0.719, P = 0.04). Our results indicate that MR imaging with Gd-EOB-DTPA is useful for evaluation of regional liver function in rats.