Combined static-dynamic MR urography for the simultaneous evaluation of morphology and function in urinary tract obstruction. II. Findings in experimentally induced ureteric stenosis

• Published in: Pediatric radiology Vol. 30; no. 8; pp. 523 - 532
• Main Authors: ROHRSCHNEIDER, W. K, BECKER, K, HOFFEND, J, CLORIUS, J. H, DARGE, K, KOOIJMAN, H, TRÖGER, J
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Berlin Springer 01.08.2000; Springer Nature B.V
• Subjects: Animals; Biological and medical sciences; Hydronephrosis - diagnosis; Hydronephrosis - physiopathology; Investigative techniques, diagnostic techniques (general aspects); Kidney - diagnostic imaging; Kidney - physiopathology; Magnetic Resonance Imaging; Medical sciences; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radionuclide Imaging; Swine; Ultrasonography; Ureteral Obstruction - diagnosis; Ureteral Obstruction - diagnostic imaging; Urinary system; Urography; Animal model; Urinary system disease; Radiodiagnosis; Stenosis; Ureteral disease; Urinary tract disease; Urinary tract; Nuclear magnetic resonance imaging; Obstruction; Dynamic method; Static method; Vertebrata; Experimental disease; Mammalia; Urography; Swine; Animal; Morphology; Medical imagery; Artiodactyla; Technique; Ureter; Ungulata
• ISSN: 0301-0449; 1432-1998
• DOI: 10.1007/s002470000273

To assess the diagnostic value of combined static-dynamic MR urography (MRU) for the functional-morphological evaluation of experimentally induced urinary tract obstruction in the piglet. In 20 piglets unilateral ureteric stenosis was created operatively. Post-surgery repeated comparative examinations were obtained with MRU, diuretic renal scintigraphy (DRS), excretory urography (EU) and ultrasound (US). MRU was performed as a combination study with a static 3D-IR-TSE sequence and a dynamic 2D-FFE sequence after Gd-DTPA with frusemide administration. MRU allowed complete depiction of the prestenotic urinary tract and of the stenosis in all cases. In 43 comparative studies MRU was superior to EU in 36, EU to MRU in 2. When single kidney function was calculated with both MRU and DRS, results were highly correlated (r = 0.92). When urinary excretion was compared, significant agreement was achieved with concordant findings in 86% and slightly discordant results in 12%. Static-dynamic MR urography permits excellent depiction of experimentally induced urinary tract obstruction in piglets and reliable assessment of individual renal function and urinary excretion. Two advantages of the method stand out--it does not require radiation and it permits functional-morphological correlation.