Elevated levels of soluble E-selectin in diabetic patients with severe symptomatic peripheral arterial occlusive disease requiring angioplasty : A possible role in diabetic vascular disease?

• Published in: International angiology Vol. 19; no. 2; pp. 171 - 175
• Main Authors: ELHADD, T. A, KENNEDY, G, MCLAREN, M, STONEBRIDGE, P. A, SHAW, W. J, BELCH, J. J. F
• Format: Journal Article
• Language: English
• Published: Torino Minerva Medica 01.06.2000; Edizioni Minerva Medica
• Subjects: Angioplasty, Balloon; Biological and medical sciences; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - complications; Diabetic Angiopathies - blood; Diabetic Angiopathies - therapy; Diseases of the cardiovascular system; E-Selectin - blood; Female; Humans; Male; Medical sciences; Middle Aged; Peripheral Vascular Diseases - blood; Peripheral Vascular Diseases - etiology; Peripheral Vascular Diseases - therapy; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Endocrinopathy; Human; Endothelial cell; Pathophysiology; E Selectin; Instrumentation therapy; Lower limb; Cuffed tube; Cardiovascular disease; Instrumental dilatation; Non insulin dependent diabetes; Artery; Arterial disease; Vascular disease; Occlusive arterial disease; Complication; Comparative study
• ISSN: 0392-9590; 1827-1839

To study levels of E-selectin in patients with peripheral arterial occlusive disease who were undergoing percutaneous transluminal angioplasty. Experimental design and setting: Cross sectional case control study, conducted in a teaching hospital. Seven patients with type-2 (non-insulin dependent) diabetes mellitus undergoing transluminal angioplasty for symptomatic peripheral arterial occlusive disease, had blood tests for sE-selectin measurement, and were compared to a similar groups of age and sex matched non-diabetic patients with arteriopathy who are undergoing the same procedure. Also evaluated were a group of diabetic patients and healthy non-diabetics with no peripheral arterial disease. The levels of sE-selectin in the two diabetic groups were significantly higher than the non-diabetic groups measuring at 77 ng/ml (53-120) and 79 ng/ml (43-98) (median, range) vs 54 ng/ml (24-104) in the non-diabetic with arteriopathy, and 42 ng/ml (35-66) in the normal healthy controls, p<0.04, p<0.003 respectively, Mann Whitney "U" test. We have demonstrated significantly high values of soluble E-selectin in patients with diabetes mellitus requiring angioplasty for symptomatic peripheral arterial occlusive disease. This suggests that sE-selectin may be involved in the diabetic angiopathic process. It may act as a precursor for smooth muscle proliferation.