Histologic morphometry confirms a prophylactic effect for hyperbaric oxygen in the prevention of delayed radiation enteropathy

In a previous publication (Feldmeier et al., Radiother Oncol 1995; 35:138-144) we reported our success in preventing delayed radiation enteropathy in a murine model by the application of hyperbaric oxygen (HBO2). In this study we introduce a histologic morphometric technique for assessing fibrosis i...

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Published inUndersea & hyperbaric medicine Vol. 25; no. 2; pp. 93 - 97
Main Authors FELDMEIER, J. J, DAVOLT, D. A, COURT, W. S, ONODA, J. M, ALECU, R
Format Journal Article
LanguageEnglish
Published Kensington, MD Undersea and Hyperbaric Medical Society 01.06.1998
Undersea & Hyperbaric Medical Society
Subjects
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Emergency and intensive care: techniques, logistics
Female
Hyperbaric Oxygenation
Intensive care medicine
Intestinal Diseases - prevention & control
Intestinal Mucosa - radiation effects
Medical sciences
Mice
Perfusions. Catheterizations. Hyperbaric oxygenotherapy
Radiation Injuries, Experimental - prevention & control
Radiation therapy and radiosensitizing agent
Rats
Rats, Inbred Strains
Treatment with physical agents
Treatment. General aspects
Tumors
Animal model
Radioprotector
Rodentia
Hyperbaric oxygen
Histology
Radiotherapy
Small intestine
Prevention
Vertebrata
Mammalia
Mouse
Animal
Disease of the small intestine
Radiation injury
Digestive diseases
Intestinal disease
Complication
Morphometry
Hyperbaric oxygenotherapy
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Summary:In a previous publication (Feldmeier et al., Radiother Oncol 1995; 35:138-144) we reported our success in preventing delayed radiation enteropathy in a murine model by the application of hyperbaric oxygen (HBO2). In this study we introduce a histologic morphometric technique for assessing fibrosis in the submucosa of these same animal specimens and relate this assay to the previous results. The histologic morphometry, like the previous gross morphometry and compliance assays, demonstrates a significant protective effect for HBO2. The present assay is related to the previous assays in a statistically significant fashion. The predictive value for the histologic morphometric assay demonstrates a sensitivity of 75% and a specificity of 62.5%. The applicability of this assay to other organ systems and its potential superiority to the compliance assay are discussed.
ISSN:1066-2936