Determining the identifiability of DNA database entries

CleanGene is a software program that helps determine the identifiability of sequenced DNA, independent of any explicit demographics or identifiers maintained with the DNA. The program computes the likelihood that the release of DNA database entries could be related to specific individuals that are t...

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Bibliographic Details
Published inProceedings - AMIA Symposium pp. 537 - 541
Main Authors Malin, B, Sweeney, L
Format Journal Article
LanguageEnglish
Published United States American Medical Informatics Association 2000
Subjects
Confidentiality
Databases, Factual
DNA
Female
Genetic Diseases, Inborn - genetics
Humans
Male
Software
Online AccessGet full text
ISSN1531-605X

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Summary:CleanGene is a software program that helps determine the identifiability of sequenced DNA, independent of any explicit demographics or identifiers maintained with the DNA. The program computes the likelihood that the release of DNA database entries could be related to specific individuals that are the subjects of the data. The engine within CleanGene relies on publicly available health care data and on knowledge of particular diseases to help relate identified individuals to DNA entries. Over 20 diseases, ranging over ataxias, blood diseases, and sex-linked mutations are accounted for, with 98-100% of individuals found identifiable. We assume the genetic material is released in a linear sequencing format from an individual's genome. CleanGene and its related experiments are useful tools for any institution seeking to provide anonymous genetic material for research purposes.
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ISSN:1531-605X