Severe local reaction following live measles virus in guinea pigs previously inoculated with killed virus

Guinea pigs were immunized with inactivated measles virus. When challenged with live virus by the intradermal route, most of the animals developed an area of erythema within 24 to 48 hours; however, an unexpected feature of the skin-testing was that some of the guinea pigs developed a very severe ne...

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Bibliographic Details
Published inCanadian journal of comparative medicine Vol. 33; no. 4; pp. 261 - 263
Main Authors Matte, V, Lussier, G, Pavilania, V, Ast, O
Format Journal Article
LanguageEnglish
Published Canada 01.10.1969
Subjects
Animals
Erythema - immunology
Guinea Pigs
Histocytochemistry
Immunization
Measles Vaccine
Measles virus
Necrosis
Skin - pathology
Skin Tests
Time Factors
Virus Cultivation
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Summary:Guinea pigs were immunized with inactivated measles virus. When challenged with live virus by the intradermal route, most of the animals developed an area of erythema within 24 to 48 hours; however, an unexpected feature of the skin-testing was that some of the guinea pigs developed a very severe necrotic reaction by the sixth or seventh day.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0008-4050