Premenstrual mood changes in affective disorders

Mood changes during the premenstrual phase have been the focus of considerable research in recent years. Although there has been significant progress in the diagnosis and etiology of major affective disorders, the relation between these disorders and menstrual changes remains controversial. There ha...

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Bibliographic Details
Published inCanadian Medical Association journal (CMAJ) Vol. 136; no. 10; pp. 1027 - 1032
Main Authors Ghadirian, A M, Kamaraju, L S
Format Journal Article
LanguageEnglish
Published Canada 15.05.1987
Subjects
Adult
Estrogens - metabolism
Female
Humans
Mood Disorders - complications
Premenstrual Syndrome - complications
Premenstrual Syndrome - genetics
Premenstrual Syndrome - metabolism
Premenstrual Syndrome - psychology
Progesterone - metabolism
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Summary:Mood changes during the premenstrual phase have been the focus of considerable research in recent years. Although there has been significant progress in the diagnosis and etiology of major affective disorders, the relation between these disorders and menstrual changes remains controversial. There have been contradictory reports and speculations on women's susceptibility to psychiatric disorders during the premenstrual phase. We describe three patients with a history of mood swings associated with menstruation in whom major affective disorders developed, necessitating intensive psychiatric treatment or admission to hospital. Among women who manifest menstrual mood changes, manic-depressive illness may develop only in a subgroup with genetic predisposition. In such cases the possibility of postpartum mania or depression should be kept in mind in follow-up.
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ISSN:0820-3946
1488-2329