Studies on the prophylactic and radical curative activity of RC-12 against Plasmodium cynomolgi in Macaca mulatta

The compound 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine (RC-12) has been shown to be active against the exoerythrocytic (EE) stages of the malaria parasite. Experiments on Plasmodium cynomolgi in rhesus monkeys showed that single weekly doses of 25 mg per kg of body weight...

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Published inBulletin of the World Health Organization Vol. 47; no. 3; pp. 425 - 428
Main Authors Sodeman, T M, Contacos, P G, Collins, W E, Smith, C S, Jumper, J R
Format Journal Article
LanguageEnglish
Published Switzerland 1972
Subjects
Animals
Brief Communications/Notes
Ethylenediamines - pharmacology
Haplorhini
Macaca
Malaria - drug therapy
Malaria - prevention & control
Malaria - veterinary
Monkey Diseases - drug therapy
Plasmodium - drug effects
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Summary:The compound 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine (RC-12) has been shown to be active against the exoerythrocytic (EE) stages of the malaria parasite. Experiments on Plasmodium cynomolgi in rhesus monkeys showed that single weekly doses of 25 mg per kg of body weight would prevent the development and/or maturation of EE stages. The usefulness of RC-12 for effecting radical cures is, however, still open to doubt.
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From the Section on Primate Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Chamblee, Ga., USA.
ISSN:0042-9686