Studies on the prophylactic and radical curative activity of RC-12 against Plasmodium cynomolgi in Macaca mulatta
The compound 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine (RC-12) has been shown to be active against the exoerythrocytic (EE) stages of the malaria parasite. Experiments on Plasmodium cynomolgi in rhesus monkeys showed that single weekly doses of 25 mg per kg of body weight...
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Published in | Bulletin of the World Health Organization Vol. 47; no. 3; pp. 425 - 428 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
1972
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Subjects | |
Online Access | Get full text |
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Summary: | The compound 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine (RC-12) has been shown to be active against the exoerythrocytic (EE) stages of the malaria parasite. Experiments on Plasmodium cynomolgi in rhesus monkeys showed that single weekly doses of 25 mg per kg of body weight would prevent the development and/or maturation of EE stages. The usefulness of RC-12 for effecting radical cures is, however, still open to doubt. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 From the Section on Primate Malaria, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Chamblee, Ga., USA. |
ISSN: | 0042-9686 |