Correlation if circulating immune complexes and disease status in patients with leukaemia

• Published in: Clinical and experimental immunology Vol. 43; no. 1; pp. 46 - 53
• Main Authors: Hubbard, R A, Aggio, M C, Lozzio, B B, Wust, C J
• Format: Journal Article
• Language: English
• Published: England 01.01.1981
• Subjects: Antigen-Antibody Complex - analysis; Centrifugation, Density Gradient; Humans; Leukemia - immunology; Prognosis; Radioimmunoassay
• ISSN: 0009-9104; 1365-2249

The occurrence of soluble immune complexes (IC) was investigated in 177 serum samples from 92 patients with various leukaemias using the Raji cell immunoassay. In general, patients with myeloproliferative diseases had a higher incidence and higher quantities of IC than did patients with lymphoproliferative disorders. Elevated levels of IC were found in the sera of patients as follows: 17% with chronic lymphocytic leukaemia (mean value of 13.1 microgram/ml), 67% with acute lymphocytic leukaemia (54.1 microgram/ml), 65% with chronic myelocytic leukaemia (86.7 microgram/ml), 70% with acute myelocytic leukaemia (202.5 microgram/ml) and 56% with acute myelomonocytic leukaemia (41.9 microgram/ml). Patients in terminal blastic crisis of chronic myelocytic leukaemia had the highest levels, with a mean level of 1,364.1 microgram/ml. Serial samples were obtained, as available, from individual patients during the course of the disease in an attempt to relate severity with the incidence and quantity of IC. No significant correlation could be made between the occurrence or levels of IC and the presence of absence of systemic symptoms. Similarly, no correlations could be made between levels of IC and haematological parameters, infection, or therapy. However, the data does indicate a positive relationship between the levels of IC and the progressive state of the leukaemia, especially, the myelocytic leukaemias.