Filamentous Artificial Virus from a Self‐Assembled Discrete Nanoribbon

Therapeutic viruses: A filament‐shaped artificial virus is formed by using a preorganized supramolecular nanoribbon as a template. The artificial virus (see picture), which is composed of the nanoribbon, small interfering RNAs (blue, double‐helix shape), and hydrophobic guests (red), is highly effic...

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Published inAngewandte Chemie International Edition Vol. 47; no. 24; pp. 4525 - 4528
Main Authors Lim, Yong‐beom, Lee, Eunji, Yoon, You‐Rim, Lee, Myeong Sup, Lee, Myongsoo
Format Journal Article
LanguageEnglish
Published Weinheim WILEY‐VCH Verlag 01.01.2008
Subjects
Biomimetic Materials - chemical synthesis
drug delivery
Drug Delivery Systems
HeLa Cells
Humans
Macromolecular Substances - chemistry
nanomaterials
Nanostructures - chemistry
peptides
Peptides - chemistry
RNA, Small Interfering - chemistry
supramolecular chemistry
viruses
Viruses - chemistry
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Summary:Therapeutic viruses: A filament‐shaped artificial virus is formed by using a preorganized supramolecular nanoribbon as a template. The artificial virus (see picture), which is composed of the nanoribbon, small interfering RNAs (blue, double‐helix shape), and hydrophobic guests (red), is highly efficient in delivering genes and drugs to the inside of cells.
Bibliography:We gratefully acknowledge the National Creative Research Initiative Program of the Korean Ministry of Science and Technology for financial support of this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200800266