T2‐oximetry–based cerebral venous oxygenation mapping using Fourier‐transform–based velocity‐selective pulse trains

• Published in: Magnetic resonance in medicine Vol. 88; no. 3; pp. 1292 - 1302
• Main Authors: Li, Wenbo, Xu, Feng, Zhu, Dan, Zijl, Peter C. M., Qin, Qin
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.09.2022
• Subjects: arterial nulling; Blood; Blood flow; Capillary flow; cerebral venous oxygenation; Contamination; Fourier transforms; Inversion; Jugular vein; Mapping; mitigate CSF contamination; Oximetry; Oxygen consumption; Oxygenation; Saturation; Velocity; velocity‐selective pulse train; venous cerebral blood
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/mrm.29300

Purpose To develop a T2‐oximetry method for quantitative mapping of cerebral venous oxygenation fraction (Yv) using Fourier‐transform–based velocity‐selective (FT‐VS) pulse trains. Methods The venous isolation preparation was achieved by using an FT‐VS inversion plus a nonselective inversion (NSI) pulse to null the arterial blood signal while minimally affected capillary blood flows out into the venular vasculature during the outflow time (TO), and then applying an Fourier transform based velocity selective saturation (FT‐VSS) pulse to suppress the tissue signal. A multi‐echo readout was employed to obtain venous T2 (T2,v) efficiently with the last echo used to detect the residual CSF signal and correct its contamination in the fitting. Here we compared the performance of this FT‐VS–based venous isolation preparations with a traditional velocity‐selective saturation (VSS)–based approach (quantitative imaging of extraction of oxygen and tissue consumption [QUIXOTIC]) with different cutoff velocities for Yv mapping on 6 healthy volunteers at 3 Tesla. Results The FT‐VS–based methods yielded higher venous blood signal and temporal SNR with less CSF contamination than the velocity‐selective saturation–based results. The averaged Yv values across the whole slice measured in different experiments were close to the global Yv measured from the individual internal jugular vein. Conclusion The feasibility of the FT‐VS–based Yv estimation was demonstrated on healthy volunteers. The obtained high venous signal as well as the mitigation of CSF contamination led to a good agreement between the T2,v and Yv measured in the proposed method with the values in the literature.