Autism and Gut-Brain Axis: Role of Probiotics

• Published in: Advances in neurobiology Vol. 24; p. 587
• Main Authors: Chidambaram, Saravana Babu, Tuladhar, Sunanda, Bhat, Abid, Mahalakshmi, Arehally Marappa, Ray, Bipul, Essa, Musthafa Mohamed, Bishir, Muhammed, Bolla, Srinivasa Rao, Nanjaiah, Nandakumar Dalavaikodihalli, Guillemin, Gilles J, Qoronfleh, M Walid
• Format: Journal Article
• Language: English
• Published: United States 2020
• Subjects: Autistic Disorder - diet therapy; Autistic Disorder - metabolism; Autistic Disorder - psychology; Brain - physiopathology; Dietary Carbohydrates - metabolism; Gastrointestinal Tract - physiopathology; Humans; Probiotics - therapeutic use; Autism; Probiotics; ASD; Cognitive and behavioural deficits; GI dysfunction; Barrier pathway; Gut–brain axis; Microbiome
• ISSN: 2190-5215
• DOI: 10.1007/978-3-030-30402-7_21

Characterized by a wide range of behavioural, social and language problems, autism is a complex developmental disability that affects an individual's capacity to communicate and interact with others. Although the real causes that lead to the development of autism are still unclear, the gastrointestinal tract has been found to play a major role in the development of autism. Alterations in macrobiotic compositions have been reported in autistic children. Irregularities in carbohydrate digestion and absorption could also explain some of the gastrointestinal problems reported in autistic patients, although their role in the neurological and behavioural problems remains uncertain. A relationship between improved gut health and decrease of symptoms in autism has been reported as well. Studies done to evaluate the gluten-free diets, casein-free diets, pre- and probiotic and multivitamin supplementation have shown promising results. Probiotics have been thought to alleviate the progression of autism and reduce cognitive and behavioural deficits.