Equipment for large-scale mammalian cell culture

This chapter provides information on commonly used equipment in industrial mammalian cell culture, with an emphasis on bioreactors. The actual equipment used in the cell culture process can vary from one company to another, but the main steps remain the same. The process involves expansion of cells...

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Bibliographic Details
Published inAdvances in biochemical engineering, biotechnology Vol. 139; p. 69
Main Author Ozturk, Sadettin S
Format Journal Article
LanguageEnglish
Published Germany 2014
Subjects
Batch Cell Culture Techniques - instrumentation
Cell Separation - instrumentation
Drug Design
Equipment Design
Equipment Failure Analysis
Protein Engineering - instrumentation
Recombinant Proteins - biosynthesis
Recombinant Proteins - therapeutic use
Robotics - methods
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Summary:This chapter provides information on commonly used equipment in industrial mammalian cell culture, with an emphasis on bioreactors. The actual equipment used in the cell culture process can vary from one company to another, but the main steps remain the same. The process involves expansion of cells in seed train and inoculation train processes followed by cultivation of cells in a production bioreactor. Process and equipment options for each stage of the cell culture process are introduced and examples are provided. Finally, the use of disposables during seed train and cell culture production is discussed.
ISSN:0724-6145
DOI:10.1007/10_2013_259