Amino Acid Hydration Decreases Radiation-Induced Nausea in Mice: A Pica Model

Nausea and diarrhea are common yet inconsistent side effects of abdominal and pelvic irradiation. Their frequency, chronicity, and severity vary greatly, and the reasons for inter-subject variability are unknown. We studied the potential for radiation-induced changes in amino acid absorption and muc...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 977; pp. 59 - 65
Main Authors Yin, Liangjie, Vaught, Lauren, Okunieff, Paul, Casey-Sawicki, Katherine, Vidyasagar, Sadasivan
Format Book Chapter Journal Article
LanguageEnglish
Published Cham Springer International Publishing 2017
SeriesAdvances in Experimental Medicine and Biology
Subjects
Amino acids
Gastrointestinal toxicity
Nausea
Pica model
Radiation
Gastrointestinal toxicity
Amino acids
Nausea
Pica model
Radiation
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Summary:Nausea and diarrhea are common yet inconsistent side effects of abdominal and pelvic irradiation. Their frequency, chronicity, and severity vary greatly, and the reasons for inter-subject variability are unknown. We studied the potential for radiation-induced changes in amino acid absorption and mucosal barrier function to lead to gastrointestinal toxicity. We found profound and prolonged changes in the absorption and secretion of several electrolytes and nutrients, caused by changes in transporter function, after radiation doses as low as 1 to 3 Gy. After identifying absorbed and non-absorbed amino acids, we demonstrated the role of a beneficial amino acid drink to alleviate radiation-related gastrointestinal symptoms in a mouse model.
ISBN:9783319552293
3319552295
ISSN:0065-2598
2214-8019
DOI:10.1007/978-3-319-55231-6_9