Single-dose therapy of infectious diseases

Single-dose antimicrobial therapy has clear advantages over multiple-dose therapy. Long-acting penicillins have been used for many years in single doses for treatment of streptococcal pharyngitis and early syphilis. More recently, shorter-acting agents are used for non-invasive mucosal infections. I...

Full description

Saved in:
Bibliographic Details
Published inCanadian family physician Vol. 33; pp. 1239 - 1242
Main Author Fong, I W
Format Journal Article
LanguageEnglish
Published Canada College of Family Physicians of Canada 01.05.1987
Subjects
Disease
Drugs
Physiological aspects
Treponema pallidum
Trichomonas vaginalis
Online AccessGet full text

Cover

More Information
Summary:Single-dose antimicrobial therapy has clear advantages over multiple-dose therapy. Long-acting penicillins have been used for many years in single doses for treatment of streptococcal pharyngitis and early syphilis. More recently, shorter-acting agents are used for non-invasive mucosal infections. In trichomonas vaginitis, for instance, a 2g single dose of metronidazole is approximately 92% effective and is considered the treatment of choice. Controversy still exists about the value of single-dose therapy in women who have bacterial cystitis. However, there is good evidence that 2 or 3 double-strength tablets of co-trimoxazole are very effective and safe in the treatment of uncomplicated cystitis in healthy women.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0008-350X
1715-5258