Vaginal adenosis in Cebus apella Monkeys exposed to DES in utero

Vaginal adenosis comparable to that seen in DES-exposed human newborns exposed to diethylstilbestrol (DES) was observed in 4 (100%) female Cebus apella monkey neonates exposed to DES in utero. Columnar Epithelium lined the vaginal canal and deep crypts in the underlying stroma. The ectocervix was ma...

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Published inObstetrics and gynecology (New York. 1953) Vol. 57; no. 5; p. 629
Main Authors Johnson, L D, Palmer, A E, King, Jr, N W, Hertig, A T
Format Journal Article
LanguageEnglish
Published United States 01.05.1981
Subjects
Animals
Animals, Newborn
Cebidae
Cebus
Diethylstilbestrol
Disease Models, Animal
Female
Humans
Maternal-Fetal Exchange
Precancerous Conditions - chemically induced
Precancerous Conditions - pathology
Pregnancy
Vagina - pathology
Vaginal Neoplasms - chemically induced
Vaginal Neoplasms - pathology
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Summary:Vaginal adenosis comparable to that seen in DES-exposed human newborns exposed to diethylstilbestrol (DES) was observed in 4 (100%) female Cebus apella monkey neonates exposed to DES in utero. Columnar Epithelium lined the vaginal canal and deep crypts in the underlying stroma. The ectocervix was markedly papillary and covered with columnar epithelium that was continuous with the endocervical epithelium. By comparison, the vagina of unexposed newborn and juvenile cebus monkeys up to 15 months of age was filled with a solid core of squamous cells that also covered the cervix and extended into the endocervix. Vaginal adenosis has been produced in mice by neonatal treatment with DES. The mouse model, however, excludes the fetoplacental unit. The cebus monkey provides a model for the investigation of teratogenic effects of intrauterine exposure to DES.
ISSN:0029-7844
1873-233X