Altered prolactin bioactivity in amniotic fluid of hypertensive pregnancy

The high concentrations of prolactin (hPRL) in human amniotic fluid appear to be derived principally from maternal decidua. The present study evaluated both the biologic and immunologic activity of amniotic fluid hPRL obtained from normal and selected complicated pregnancies. Biologic and immunologi...

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Bibliographic Details
Published inObstetrics and gynecology (New York. 1953) Vol. 65; no. 1; p. 24
Main Authors McCoshen, J A, Tyson, J E
Format Journal Article
LanguageEnglish
Published United States 01.01.1985
Subjects
Amniotic Fluid - metabolism
Female
Fetus
Humans
Hypertension - metabolism
Infant, Newborn
Male
Pharynx - secretion
Phosphatidylcholines - metabolism
Phosphatidylglycerols - metabolism
Pregnancy
Pregnancy Complications, Cardiovascular - metabolism
Prolactin - analysis
Prolactin - metabolism
Radioimmunoassay
Sphingomyelins - metabolism
Suction
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Summary:The high concentrations of prolactin (hPRL) in human amniotic fluid appear to be derived principally from maternal decidua. The present study evaluated both the biologic and immunologic activity of amniotic fluid hPRL obtained from normal and selected complicated pregnancies. Biologic and immunologic activities of amniotic fluid hPRL were also compared with lecithin:sphingomyelin ratios and phosphatidylglycerol content. No significant correlation existed between amniotic fluid hPRL activities and fetal lung maturation. However, a significant increase in amniotic fluid hPRL concentration as well as specific biologic activity of the hormone was found in pregnancies complicated by hypertension. These findings suggest alterations in the synthesis of decidual hPRL and/or its transport to the amniotic fluid that may influence pregnancy-induced hypertension.
ISSN:0029-7844