Determination of ovarian function using first morning urine steroid assays

A new direct radioimmunoassay measuring ovarian steroid metabolites in small aliquots of urine has been evaluated. For this purpose urinary levels of estrone-3-glucuronide (E1G) and pregnanediol-3-glucuronide (PG) were correlated with plasma values of estradiol (E2) and progesterone (P), respectivel...

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Published inObstetrics and gynecology (New York. 1953) Vol. 58; no. 1; p. 5
Main Authors Denari, J H, Farinati, Z, Casas, P R, Oliva, A
Format Journal Article
LanguageEnglish
Published United States 01.07.1981
Subjects
Circadian Rhythm
Estradiol - blood
Estrogens - urine
Estrone - analogs & derivatives
Estrone - urine
Female
Glucuronates - urine
Humans
Luteinizing Hormone - blood
Menstruation
Ovarian Function Tests - methods
Ovulation Detection
Pregnanediol - analogs & derivatives
Pregnanediol - urine
Progesterone - blood
Radioimmunoassay
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Summary:A new direct radioimmunoassay measuring ovarian steroid metabolites in small aliquots of urine has been evaluated. For this purpose urinary levels of estrone-3-glucuronide (E1G) and pregnanediol-3-glucuronide (PG) were correlated with plasma values of estradiol (E2) and progesterone (P), respectively, from days 5 to 24 of the cycle in 24 women with normal cycles. Urine samples were representative of 1) first morning voiding; 2) 24-hour collection; and 3) all voidings except for the first morning one. The correlation between urinary E1G and PG with plasma values of E2 and P was statistically significant for the 3 collections of urine. The first morning voiding is selected as the sample of choice to determine E1G and PG due to its ease of collection and its high correlation with plasma E2 and P levels (r = .60, P less than .001; r = .73, P less than .001, respectively).
ISSN:0029-7844