Oral cyclosporine, hypertension and hypomagnesemia are possible risk factors for posterior leukoencephalopathy syndrome in a boy with aplastic anemia

Abstract This is a case of posterior leukoencephalopathy syndrome (PLES) in an 11-year-old African-American male treated with oral cyclosporine while on admission for idiopathic aplastic anemia in the intensive care unit at Louisiana State University, Shreveport, USA. The patient had tonic-clonic se...

Full description

Saved in:
Bibliographic Details
Published inJournal of pediatric neurology Vol. 7; no. 2; pp. 209 - 213
Main Authors Akingbola, Olugbenga A., Eduardo, Gonzalez-Toledo, Jeroudi, Majed A.
Format Journal Article
LanguageEnglish
Published New York Georg Thieme Verlag KG 01.06.2009
Stuttgart Thieme Medical Publishers Inc
Subjects
Blood clots
Blood products
Case Report
Drug therapy
Laboratory animals
Medical imaging
Neurology
Neurotoxicity
Nitric oxide
Patients
Pediatrics
Risk factors
Tomography
cyclosporine
hypomagnesemia
aplastic anemia
seizures
hypertension
PLES
Online AccessGet full text

Cover

More Information
Summary:Abstract This is a case of posterior leukoencephalopathy syndrome (PLES) in an 11-year-old African-American male treated with oral cyclosporine while on admission for idiopathic aplastic anemia in the intensive care unit at Louisiana State University, Shreveport, USA. The patient had tonic-clonic seizures preceded by visual hallucinations and hypertension. Magnetic resonance imaging with fluid attenuated inversion-recovery sequences revealed presence of cerebral edema in the cortical and subcortical regions of the frontal, supraventricular and posterior parietal lobes consistent with PLES. Resolution of PLES lesions occurred with a 25% reduction in dose of oral cyclosporine, control of seizure activity and treatment of hypertension. Patient recovered completely and was discharged home on anticonvulsant and antihypertensive medications that were subsequently discontinued at follow-up visit.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1304-2580
1305-0613
1875-9041
DOI:10.3233/JPN-2009-0284