Amniotic fluid adenosine 3',5' - monophosphate in prostaglandin-induced midtrimester abortions
Cyclic adenosine 3'5-monophosphate (cAMP) was serially measured in the amniotic fluid (AF) of 9 patients undergoing midtrimester abortions induced by intraamniotic prostaglandins. The results demonstrate an increase in AF cAMP ranging from 2- to 7-fold within the 6 hours of observation. The fet...
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Published in | Obstetrics and gynecology (New York. 1953) Vol. 49; no. 2; p. 223 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.02.1977
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Subjects | |
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Abstract | Cyclic adenosine 3'5-monophosphate (cAMP) was serially measured in the amniotic fluid (AF) of 9 patients undergoing midtrimester abortions induced by intraamniotic prostaglandins. The results demonstrate an increase in AF cAMP ranging from 2- to 7-fold within the 6 hours of observation. The fetal heart tones were closely monitored by a Doppler instrument and the time from injection of abortifacient to fetal demise (IDT) and to fetal expulsion (IAT) was accurately recorded. No correlation between the rate of AF cAMP increase and IDT or IAT could be demonstrated. The concentration of cAMP in amniotic fluid obtained from patients with fetal demise in utero was lower than that found in AF of fetuses of corresponding gestational age where the fetus was alive. The significance of AF cAMP as a potential indicator of fetal distress is discussed. |
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AbstractList | Cyclic adenosine 3'5-monophosphate (cAMP) was serially measured in the amniotic fluid (AF) of 9 patients undergoing midtrimester abortions induced by intraamniotic prostaglandins. The results demonstrate an increase in AF cAMP ranging from 2- to 7-fold within the 6 hours of observation. The fetal heart tones were closely monitored by a Doppler instrument and the time from injection of abortifacient to fetal demise (IDT) and to fetal expulsion (IAT) was accurately recorded. No correlation between the rate of AF cAMP increase and IDT or IAT could be demonstrated. The concentration of cAMP in amniotic fluid obtained from patients with fetal demise in utero was lower than that found in AF of fetuses of corresponding gestational age where the fetus was alive. The significance of AF cAMP as a potential indicator of fetal distress is discussed. |
Author | Roginsky, M S Weiss, P R Robins, J Macri, J N Sulimovici, S |
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Snippet | Cyclic adenosine 3'5-monophosphate (cAMP) was serially measured in the amniotic fluid (AF) of 9 patients undergoing midtrimester abortions induced by... |
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SubjectTerms | Abortion, Induced Adult Amniotic Fluid - metabolism Cyclic AMP - metabolism Female Fetal Distress - diagnosis Fetal Distress - metabolism Humans Pregnancy Pregnancy Trimester, Second Prostaglandins F - administration & dosage Prostaglandins F - therapeutic use |
Title | Amniotic fluid adenosine 3',5' - monophosphate in prostaglandin-induced midtrimester abortions |
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