Amniotic fluid adenosine 3',5' - monophosphate in prostaglandin-induced midtrimester abortions

Cyclic adenosine 3'5-monophosphate (cAMP) was serially measured in the amniotic fluid (AF) of 9 patients undergoing midtrimester abortions induced by intraamniotic prostaglandins. The results demonstrate an increase in AF cAMP ranging from 2- to 7-fold within the 6 hours of observation. The fet...

Full description

Saved in:
Bibliographic Details
Published inObstetrics and gynecology (New York. 1953) Vol. 49; no. 2; p. 223
Main Authors Weiss, P R, Sulimovici, S, Macri, J N, Robins, J, Roginsky, M S
Format Journal Article
LanguageEnglish
Published United States 01.02.1977
Subjects
Abortion, Induced
Adult
Amniotic Fluid - metabolism
Cyclic AMP - metabolism
Female
Fetal Distress - diagnosis
Fetal Distress - metabolism
Humans
Pregnancy
Pregnancy Trimester, Second
Prostaglandins F - administration & dosage
Prostaglandins F - therapeutic use
Online AccessGet more information

Cover

More Information
Summary:Cyclic adenosine 3'5-monophosphate (cAMP) was serially measured in the amniotic fluid (AF) of 9 patients undergoing midtrimester abortions induced by intraamniotic prostaglandins. The results demonstrate an increase in AF cAMP ranging from 2- to 7-fold within the 6 hours of observation. The fetal heart tones were closely monitored by a Doppler instrument and the time from injection of abortifacient to fetal demise (IDT) and to fetal expulsion (IAT) was accurately recorded. No correlation between the rate of AF cAMP increase and IDT or IAT could be demonstrated. The concentration of cAMP in amniotic fluid obtained from patients with fetal demise in utero was lower than that found in AF of fetuses of corresponding gestational age where the fetus was alive. The significance of AF cAMP as a potential indicator of fetal distress is discussed.
ISSN:0029-7844