Prenatal genetic diagnosis in 350 amniocenteses

Three hundred and fifty second trimester amniocenteses performed for prenatal diagnosis of genetic disorders are reported. One hundred and ninety-three of these were performed because maternal age was greater than 35 years, and 6 fetuses with unbalanced chromosomal abnormalities (3%) were identified...

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Bibliographic Details
Published inObstetrics and gynecology (New York. 1953) Vol. 48; no. 2; p. 158
Main Authors Crandall, B F, Lebherz, T B
Format Journal Article
LanguageEnglish
Published United States 01.08.1976
Subjects
Adult
Amniocentesis
Central Nervous System - abnormalities
Chromosome Aberrations - diagnosis
Chromosome Disorders
Congenital Abnormalities - diagnosis
Down Syndrome - diagnosis
Female
Fetal Diseases - diagnosis
Humans
Infant, Newborn
Klinefelter Syndrome - diagnosis
Male
Maternal Age
Mosaicism
Pregnancy
Pregnancy Trimester, Second
Sex Chromosome Aberrations - diagnosis
Trisomy
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Summary:Three hundred and fifty second trimester amniocenteses performed for prenatal diagnosis of genetic disorders are reported. One hundred and ninety-three of these were performed because maternal age was greater than 35 years, and 6 fetuses with unbalanced chromosomal abnormalities (3%) were identified. Thirteen procedures were performed because a previous child had had a neural tube defect; 1 anencephalic fetus was identified. Ninety-six percent of the initial taps were cultured successfully; we failed to obtain amniotic fluid in 3% of patients. The risk of a spontaneous abortion occurring at some time after the amniocentesis was 0.85%, and no cases of fetal injury were identified.
ISSN:0029-7844