Antigen delivery by attenuated Bacillus anthracis: new prospects in veterinary vaccines

This report summarizes the recent investigations on the use of Bacillus anthracis as a live vector for delivery of antigens. Recombinant strains were constructed by engineering the current live Sterne vaccine. This vaccine, used to prevent anthrax in cattle, causes side‐effects due to anthrax toxin...

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Bibliographic Details
Published inJournal of applied microbiology Vol. 87; no. 2; pp. 298 - 302
Main Authors Brossier, F., Mock, M., Sirard, J. ‐C.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Science Ltd 01.08.1999
Oxford University Press
Subjects
Animals
Anthrax - immunology
Anthrax - prevention & control
Anthrax - veterinary
Antigens, Bacterial - immunology
Antigens, Bacterial - therapeutic use
Bacillus anthracis
Bacillus anthracis - immunology
Cattle
Cattle Diseases - immunology
Cattle Diseases - prevention & control
Vaccination
Vaccines, Synthetic
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Summary:This report summarizes the recent investigations on the use of Bacillus anthracis as a live vector for delivery of antigens. Recombinant strains were constructed by engineering the current live Sterne vaccine. This vaccine, used to prevent anthrax in cattle, causes side‐effects due to anthrax toxin activities. Bacteria producing a genetically detoxified toxin factor were devoid of lethal effects and were as protective as the Sterne strain against experimental anthrax. Moreover, B. anthracis expressing a foreign antigen controlled by an in vivo inducible promoter were able to generate either antibody or cellular protective responses against heterologous diseases.
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ISSN:1364-5072
1365-2672
DOI:10.1046/j.1365-2672.1999.00895.x