Progesterone concentration in placenta, molar tissue, and ovarian theca lutein cyst

Progesterone concentrations in 2 full-term normal placentas, molar tissue from 3 cases of hydatidiform mole were measured by competitive protein binding. Sephadex LH-20 column chromatographic separation of extracts from these tissues showed that, in placental and molar tissue, 85 to 95% of the extra...

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Bibliographic Details
Published inObstetrics and gynecology (New York. 1953) Vol. 45; no. 2; p. 171
Main Authors Dawood, M Y, Teoh, E S, Das, N P
Format Journal Article
LanguageEnglish
Published United States 01.02.1975
Subjects
Chorionic Gonadotropin - secretion
Chromatography
Chromatography, Gel
Female
Humans
Hydatidiform Mole - analysis
Hydroxyprogesterones - analysis
Hysterectomy
In Vitro Techniques
Ovarian Neoplasms - analysis
Placenta - analysis
Pregnancy
Pregnancy Trimester, First
Progesterone - analysis
Thecoma - analysis
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Summary:Progesterone concentrations in 2 full-term normal placentas, molar tissue from 3 cases of hydatidiform mole were measured by competitive protein binding. Sephadex LH-20 column chromatographic separation of extracts from these tissues showed that, in placental and molar tissue, 85 to 95% of the extracts were progesterone and very small amounts of 20 alpha-dihydroprogesterone and 17 alpha-hydroxyprogesterone. The concentration of progesterone in the placenta were 368.8 and 317.2 ng/g tissue, respectively, while in molar tissue the concentration were 2474.5, 1974.6, and 4146.0 ng/g tissue, respectively. Progesterone concentration in ovarian tissue was between 1121;2 and 1440.9 ng/g tissue. It is suggested that the high concentration of progesterone in molar tissue reflects functional capacity of the abnormal trophoblast in progesterone synthesis and accumulation of progesterone due to absence of a fetus. The lower concentration of progesterone in the ovary in molar pregnancy would appear to suggest that the ovary is a secondary source of progesterone in molar pregnancy.
ISSN:0029-7844