Target-triggered, self-powered DNAzyme–MnO2 nanosystem: towards imaging microRNAs in living cells

• Published in: Chemical communications (Cambridge, England) Vol. 55; no. 89; pp. 13366 - 13369
• Main Authors: Cui, Mei-Rong, Li, Xiang-Ling, Xu, Jing-Juan, Chen, Hong-Yuan
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 05.11.2019
• Subjects: chemical compounds; chemical reactions; image analysis; Manganese dioxide; microRNA; MicroRNAs; monitoring; nanotechnology; Target recognition

A target-triggered, self-powered strategy for in situ monitoring of intracellular microRNAs was fabricated via a versatile DNAzyme–MnO2 nanosystem, which integrates delivery, quenching, target recognition, self-supply of cofactors and signal amplification all in one.