Target-triggered, self-powered DNAzyme–MnO2 nanosystem: towards imaging microRNAs in living cells

A target-triggered, self-powered strategy for in situ monitoring of intracellular microRNAs was fabricated via a versatile DNAzyme–MnO2 nanosystem, which integrates delivery, quenching, target recognition, self-supply of cofactors and signal amplification all in one.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 55; no. 89; pp. 13366 - 13369
Main Authors Cui, Mei-Rong, Li, Xiang-Ling, Xu, Jing-Juan, Chen, Hong-Yuan
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 05.11.2019
Subjects
chemical compounds
chemical reactions
image analysis
Manganese dioxide
microRNA
MicroRNAs
monitoring
nanotechnology
Target recognition
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Summary:A target-triggered, self-powered strategy for in situ monitoring of intracellular microRNAs was fabricated via a versatile DNAzyme–MnO2 nanosystem, which integrates delivery, quenching, target recognition, self-supply of cofactors and signal amplification all in one.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c9cc06623c