Dysregulation of microRNAs in angioimmunoblastic T-cell lymphoma

• Published in: Anticancer research Vol. 35; no. 4; pp. 2055 - 2061
• Main Authors: Reddemann, Katharina, Gola, Damian, Schillert, Arne, Knief, Juliana, Kuempers, Christiane, Ribbat-Idel, Julika, Ber, Svetlana, Schemme, Janina, Bernard, Veronica, Gebauer, Niklas, Feller, Alfred Christian, Thorns, Christoph
• Format: Journal Article
• Language: English
• Published: Greece 01.04.2015
• Subjects: Adult; Aged; Aged, 80 and over; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Lymph Nodes - pathology; Lymphadenitis - genetics; Lymphadenitis - pathology; Lymphoma, T-Cell, Peripheral - genetics; Lymphoma, T-Cell, Peripheral - pathology; Male; MicroRNAs - biosynthesis; MicroRNAs - genetics; Middle Aged; Angioimmunoblastic T-cell lymphoma; microRNA; lymphadenitis with T-zone hyperplasia
• ISSN: 0250-7005; 1791-7530

Angioimmunoblastic T-cell lymphomas (AITLs) are the second most frequent peripheral T-cell lymphomas in humans worldwide and histomorphologically well characterized. MicroRNAs are a group of small non-coding RNAs that can negatively regulate gene expression on a posttranscriptional level. Their dysregulation has been shown to be of importance in numerous tumour entities. As a first step towards understanding the possible influence of microRNA-dysregulation in AITL, we analyzed the expression signatures of 760 microRNAs in 30 nodal AITLs in comparison to reactive lymphadenitis with T-zone hyperplasia. We found miR-34a, miR-146a and miR-193b to be up-regulated, as well as miR-140-3p, let-7g, miR-30b and miR-664 to be down-regulated in AITL to a significant level. The microRNA-signatures of AITL reveal some overlap to autoimmune diseases, virus-triggered lymphomas and angiogenic factors that, coupled with future studies, will potentially provide better understanding of this disease.