Hypofractionated stereotactic radiotherapy with the hypoxic sensitizer AK-2123 (sanazole) for reirradiation of brain metastases: a preliminary feasibility report

Reirradiation is a challenging field in the treatment of recurrent brain metastases. Because of the elevated risk of radiation toxicity due to previous irradiation, only a limited dose is prescribed. To enhance radiosensitivity, in the present analysis six patients received hypofractionated stereota...

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Published inAnticancer research Vol. 33; no. 4; pp. 1773 - 1776
Main Authors Yamazaki, Hideya, Nakamura, Satoaki, Nishimura, Takuya, Kodani, Naohiro, Tsubokura, Takuji, Kimoto, Takuya, Sihomi, Hiroya, Aibe, Norihiro, Yoshida, Ken, Koizumi, Masahiko, Kagiya, Tsutomu
Format Journal Article
LanguageEnglish
Published Greece 01.04.2013
Subjects
Administration, Oral
Adult
Aged
Brain
Brain Neoplasms - drug therapy
Brain Neoplasms - radiotherapy
Brain Neoplasms - secondary
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Combined Modality Therapy
Cranial Irradiation
Dose Fractionation
Feasibility Studies
Female
Humans
Lung Neoplasms - drug therapy
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Male
Middle Aged
Prognosis
Radiation-Sensitizing Agents - administration & dosage
Radiosurgery
Triazoles - administration & dosage
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Summary:Reirradiation is a challenging field in the treatment of recurrent brain metastases. Because of the elevated risk of radiation toxicity due to previous irradiation, only a limited dose is prescribed. To enhance radiosensitivity, in the present analysis six patients received hypofractionated stereotactic radiotherapy (hSRT) with daily oral administration of the hypoxic sensitizer AK-2123 (sanazole) for progressive brain metastases after previous radiotherapy. The patients received daily oral administration of 1.0 g/day sanazole up to 2 h before radiotherapy. Three partial and three stable responses were observed, with no sanazole-related toxicity, except for a case of mild nausea. Brain failure with subsequent death occurred in one patient. The other patients maintained good performance status until disease progression in other lesions. hSRT with a hypoxic radiation sensitizer appears to have the potential to enhance the efficacy of radiotherapy.
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ISSN:0250-7005
1791-7530