3,5,6,7,8,3',4'-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model

• Published in: Neurochemistry international Vol. 70; pp. 30 - 38
• Main Authors: Okuyama, Satoshi, Morita, Mayu, Miyoshi, Kazuhiro, Nishigawa, Yuki, Kaji, Miki, Sawamoto, Atsushi, Terugo, Tsukasa, Toyoda, Nobuki, Makihata, Nahomi, Amakura, Yoshiaki, Yoshimura, Morio, Nakajima, Mitsunari, Furukawa, Yoshiko
• Format: Journal Article
• Language: English
• Published: England 01.05.2014
• Subjects: Animals; Brain Ischemia - drug therapy; Brain Ischemia - metabolism; Cell Death - drug effects; Citrus; Disease Models, Animal; Flavonoids - chemistry; Flavonoids - pharmacology; Hippocampus - drug effects; Hippocampus - metabolism; Male; Memory Disorders - drug therapy; Memory Disorders - metabolism; Mice, Inbred C57BL; Neurons - cytology; Neurons - drug effects; Neurons - metabolism; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacology; Heptamethoxyflavone; Neuronal cell protection; Global cerebral ischemia; BDNF; Anti-inflammation; Hippocampus
• ISSN: 0197-0186; 1872-9754
• DOI: 10.1016/j.neuint.2014.03.008

The present study evaluated the effects of treatment with the citrus flavonoid, 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) on protection against memory impairment and neuronal death in a global cerebral ischemia mouse model. The results showed that HMF, administrated for three days immediately after ischemic surgery, protected against ischemia-induced memory dysfunction, rescued neuronal cell death in the CA1 cell layer, increased the production of BDNF, stimulated the autophosphorylation of CaMK II and suppressed microglial activation in the hippocampus. These results suggest that HMF has a neuroprotective effect after brain ischemia by inducing BDNF production and anti-inflammatory effects.