The Swedish Two-County Trial twenty years later. Updated mortality results and new insights from long-term follow-up

The benefit of invitation to mammographic screening observed in this trial is maintained as a highly significant 32% reduction in breast cancer mortality. Mammographic screening for breast cancer continues to save lives after up to 20 years. Screening derives this benefit by improving the distributi...

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Bibliographic Details
Published inThe Radiologic clinics of North America Vol. 38; no. 4; p. 625
Main Authors Tabár, L, Vitak, B, Chen, H H, Duffy, S W, Yen, M F, Chiang, C F, Krusemo, U B, Tot, T, Smith, R A
Format Journal Article
LanguageEnglish
Published United States 01.07.2000
Subjects
Adult
Aged
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - mortality
Breast Neoplasms - prevention & control
Calcinosis - diagnostic imaging
Female
Follow-Up Studies
Humans
Longitudinal Studies
Mammography
Mass Screening
Middle Aged
Neoplasm Staging
Prognosis
Randomized Controlled Trials as Topic
Sweden
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Summary:The benefit of invitation to mammographic screening observed in this trial is maintained as a highly significant 32% reduction in breast cancer mortality. Mammographic screening for breast cancer continues to save lives after up to 20 years. Screening derives this benefit by improving the distribution of tumors diagnosed with respect to prognostic categories based on node status, size, and histology of tumors. There is potential for modern screening programs with shorter interscreening intervals to achieve even greater improvements in prognostic category and greater reductions in breast cancer mortality. Mammography can discriminate a subpopulation of high-risk cases, those displaying casting-type calcifications on the mammogram, among very small tumors, with fundamental implications for diagnosis and treatment.
ISSN:0033-8389
DOI:10.1016/S0033-8389(05)70191-3