TMEM16 proteins: Ca2+-activated chloride channels and phospholipid scramblases as potential drug targets (Review)

TMEM16 proteins, which function as Ca2+-activated Cl− channels are involved in regulating a wide variety of cellular pathways and functions. The modulators of Cl− channels can be used for the molecule-based treatment of respiratory diseases, cystic fibrosis, tumors, cancer, osteoporosis and coronavi...

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Bibliographic Details
Published inInternational journal of molecular medicine Vol. 54; no. 4
Main Authors Zhao, Zhe, Chen, Xiaoqiang, Mahmmod, Ayesha, Liu, Jianquan
Format Journal Article
LanguageEnglish
Published Athens Spandidos Publications UK Ltd 01.10.2024
D.A. Spandidos
Subjects
Binding sites
Cancer
Cystic fibrosis
Kinases
Lipids
Mutation
Proteins
Review
Tumors
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Summary:TMEM16 proteins, which function as Ca2+-activated Cl− channels are involved in regulating a wide variety of cellular pathways and functions. The modulators of Cl− channels can be used for the molecule-based treatment of respiratory diseases, cystic fibrosis, tumors, cancer, osteoporosis and coronavirus disease 2019. The TMEM16 proteins link Ca2+ signaling, cellular electrical activity and lipid transport. Thus, deciphering these complex regulatory mechanisms may enable a more comprehensive understanding of the physiological functions of the TMEM16 proteins and assist in ascertaining the applicability of these proteins as potential pharmacological targets for the treatment of a range of diseases. The present review examined the structures, functions and characteristics of the different types of TMEM16 proteins, their association with the pathogenesis of various diseases and the applicability of TMEM16 modulator-based treatment methods.
Bibliography:Contributed equally
ISSN:1107-3756
1791-244X
DOI:10.3892/ijmm.2024.5405