Magnetic resonance imaging in progressive supranuclear palsy

Progressive supranuclear palsy (PSP) is a tauopathy, presenting clinically most often with a symmetrical akinetic-rigid syndrome, postural instability, supranuclear gaze palsy and frontal dementia. In the absence of reliably validated biomarkers, the diagnosis of PSP in vivo is presently based on cl...

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Bibliographic Details
Published inJournal of neurology Vol. 258; no. 4; pp. 549 - 558
Main Authors Stamelou, M., Knake, S., Oertel, W. H., Höglinger, G. U.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.04.2011
Springer Nature B.V
Subjects
Atrophy
Biomarkers
Brain - pathology
Brain Mapping
Dementia
Humans
Image Processing, Computer-Assisted - methods
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Medicine
Medicine & Public Health
Neurology
Neuroradiology
Neurosciences
Phosphorus
Protons
Review
Spectrum analysis
Supranuclear Palsy, Progressive - diagnosis
Diffusion-tensor imaging
Proton magnetic resonance spectroscopy
Magnetic resonance imaging
Progressive supranuclear palsy
Voxel-based morphometry
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Summary:Progressive supranuclear palsy (PSP) is a tauopathy, presenting clinically most often with a symmetrical akinetic-rigid syndrome, postural instability, supranuclear gaze palsy and frontal dementia. In the absence of reliably validated biomarkers, the diagnosis of PSP in vivo is presently based on clinical criteria, which to date do not include supporting imaging findings, as is accepted for other neurodegenerative diseases. However, data from conventional magnetic resonance imaging (MRI) and various advanced MRI techniques including magnetic resonance volumetry, voxel-based morphometry, diffusion-weighted and diffusion-tensor imaging, magnetization transfer imaging and proton resonance spectroscopy suggest that MRI can contribute valuable information for the differential diagnosis of PSP. We review here the presently published literature concerning MRI in PSP and discuss the potential role of MRI in differentiating PSP from other parkinsonian syndromes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-010-5865-0