Arterial and Atherosclerotic Plaque Biomechanics with Application to Stent Angioplasty Modeling

• Published in: Biomechanics: Trends in Modeling and Simulation Vol. 20; pp. 193 - 231
• Main Authors: O’Reilly, Brían L., Conway, Claire, McGarry, J. Patrick, McHugh, Peter E.
• Format: Book Chapter
• Language: English
• Published: Switzerland Springer International Publishing AG 01.01.2017; Springer International Publishing
• Series: Studies in Mechanobiology, Tissue Engineering and Biomaterials
• Subjects: Arterial Tissue; Biomedical engineering; Continuum Damage Mechanic; Mathematical modelling; Mechanics of solids; Mullins Effect; Plaque Tissue; Rupture Stress
• ISBN: 3319414739; 9783319414737
• ISSN: 1868-2006; 1868-2014
• DOI: 10.1007/978-3-319-41475-1_5

This chapter O’Reilly, Brían L. a Conway, Claire review McGarry, J. PatrickMcHugh, Peter E. mechanics in relation to application in vascular biomechanics. The initial focus is on arterial tissue, where fundamental constitutive representations, tissue anisotropy, tissue remodeling and damage modeling are overviewed. The focus then shifts to diseased tissue (atherosclerotic plaque tissue), where experimental mechanical characterization, and constitutive and damage modeling are reviewed. Conclusions are drawn on what has been achieved thus far, and the main challenges for the future in characterizing and modeling this complex tissue are identified. Finally, the application of the arterial mechanics in the computational modeling of the stent angioplasty procedure is considered, with future challenges identified.