Association of Syndecan-1 with Angiogenesis-related Markers, Extracellular Matrix Components, and Clinicopathological Features in Colorectal Carcinoma

• Published in: Anticancer research Vol. 32; no. 9; pp. 3977 - 3985
• Main Authors: MITSELOU, Antigony, SKOUFI, Urania, TSIMOGIANNIS, Konstantinos E, BRIASOULIS, Evagelos, VOUGIOUKLAKIS, Theodoros, ARVANITIS, Dimitris, IOACHIM, Elli
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01.09.2012
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Collagen Type IV - biosynthesis; Colorectal Neoplasms - blood supply; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Extracellular Matrix - metabolism; Extracellular Matrix - pathology; Female; Fibronectins - biosynthesis; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Immunohistochemistry; Laminin - biosynthesis; Male; Medical sciences; Middle Aged; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Syndecan-1 - biosynthesis; Tenascin - biosynthesis; Tumors; Rectal disease; Colorectal carcinoma; Colorectal cancer; Biological marker; Syndecan 1; Malignant tumor; Colonic disease; Angiogenesis; Cancerology; Digestive diseases; Intestinal disease; Extracellular matrix; Syndecan-1; Neovascularization; Cancer
• ISSN: 0250-7005; 1791-7530

Syndecan-1 is a transmembrane heparansulfate proteoglycan, which regulates cell proliferation, migration, angiogenesis, cell-to-cell and cell-to-extracellular matrix adhesion and may influence malignant cell behavior. We investigated the alterations of syndecan-1 expression in colorectal cancer and analyzed the relationship between clinicopathological parameters, proliferation indices, angiogenic markers, and extracellular matrix components. Syndecan-1 protein expression observed in the tumorous epithelium was high in 52/97 (53.6%) of the studied cases, moderate in 20/97 (20.6%), and weak in 5/97 (5.22%) of the cases, and there was strong stromal expression in 34.02% of the tumors. Syndecan-1 expression was statistically correlated to VEGF expression in tumor (p=0.001) and vessels (p=0.007). In addition, there was a borderline correlation between syndecan-1 expression and tenascin (p=0.053). Patients with weak staining reaction had a more unfavorable prognosis (p=0.032) in univariate analysis. These results indicate the implication of syndecan-1 in the remodeling and angiogenesis of colorectal cancer tissue, through interaction with other extracellular matrix components and VEGF, probably influencing the tumor progression and aggressiveness.