Interstitial Cells of Cajal and Intestinal Function in Trinidadian Children

This study was carried out to compare the density of the interstitial cells of Cajal (ICCs) in the bowel wall of children with Hirschsprung's disease (HD), anorectal malformations (ARM) and normal controls in Trinidad and Tobago. Segments of bowel wall excised from eight children with HD, three...

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Published inWest Indian medical journal Vol. 57; no. 4; pp. 393 - 397
Main Authors ANATOL, T, MOHAMMED, W, RAO, C
Format Journal Article
LanguageEnglish
Published Mona University of West Indies, Faculty of Medical Sciences 01.09.2008
Subjects
Adolescent
Anal Canal - abnormalities
Anal Canal - cytology
Anal Canal - pathology
Biological and medical sciences
Case-Control Studies
Cell Count
Child
Child, Preschool
Female
Gastrointestinal Motility - physiology
General aspects
Hirschsprung Disease - diagnosis
Hirschsprung Disease - pathology
Humans
Infant
Interstitial Cells of Cajal - cytology
Interstitial Cells of Cajal - pathology
Intestines - abnormalities
Intestines - cytology
Intestines - pathology
Male
Mass Screening
Medical sciences
Muscle, Smooth - abnormalities
Muscle, Smooth - cytology
Muscle, Smooth - pathology
Proto-Oncogene Proteins c-kit
Trinidad and Tobago
Trinidad and Tobago
Human
Interstitial cell
Cell function
Child
Gut
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Summary:This study was carried out to compare the density of the interstitial cells of Cajal (ICCs) in the bowel wall of children with Hirschsprung's disease (HD), anorectal malformations (ARM) and normal controls in Trinidad and Tobago. Segments of bowel wall excised from eight children with HD, three controls and two children with ARM were immunostained with c-Kit primary antibody. Cells with features of ICCs were counted. All three controls and the two children with ARM had dense distribution of ICCs. Most children (6/8; 75%) with HD had markedly reduced counts in aganglionic bowel. Two (25%) also had a decrease in ganglionic bowel. Possible influences were patient age and gender and the level of bowel sectioned. Analysis of this sample suggests that immunostaining for c-Kit positive cells might be a useful screening test in the assessment of bowel motility disorders. The possible effects of age, gender and the level of bowel sampled await determination.
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ISSN:0043-3144