Immunohistochemical Expression and Prognostic Significance of CCND3, MCM2 and MCM7 in Hodgkin Lymhoma

• Published in: Anticancer research Vol. 31; no. 10; pp. 3585 - 3594
• Main Authors: MARNERIDES, Andreas, VASSILAKOPOULOS, Theodoros P, PANGALIS, Gerassimos A, BERIS, Photis, PATSOURIS, Efstratios, KORKOLOPOULOU, Penelope, BOLTETSOU, Evmorfia, LEVIDOU, Georgia, ANGELOPOULOU, Maria K, THYMARA, Irene, KYRTSONIS, Marie-Christine, PAPPI, Vassiliki, TSOPRA, Olga, PANAYIOTIDIS, Panayiotis
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01.10.2011
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Biomarkers, Tumor - metabolism; Cell Cycle Proteins - metabolism; Cell Proliferation; Cyclin D3 - metabolism; Disease-Free Survival; DNA-Binding Proteins - metabolism; Female; Hematologic and hematopoietic diseases; Hodgkin Disease - metabolism; Hodgkin Disease - pathology; Humans; Immunohistochemistry; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Minichromosome Maintenance Complex Component 2; Minichromosome Maintenance Complex Component 7; Multivariate Analysis; Nuclear Proteins - metabolism; Prognosis; Tumors; Young Adult; Immunohistochemistry; Minichromosome maintenance proteins; Prognosis; Minichromosome maintenance protein 7; Hodgkin disease; Malignant hemopathy; Lymphoma; Survival; Cyclin D3; Anatomic pathology; CCND3; Cancerology; Lymphoproliferative syndrome; MCMs; Minichromosome; Cancer; Hodgkin lymphoma
• ISSN: 0250-7005; 1791-7530

Increased proliferation rate may be associated with inferior outcome in patients with Hodgkin lymphoma (HL). Minichromosome maintenance proteins (MCMs) and D-type cyclins are essential for DNA replication. Lymph node sections from 138 HL patients were immunohistochemically stained for cyclin D3 (CCND3), MCM2 and MCM7 aiming to investigate clinical outcome. Higher MCM2 expression was observed in patients in early stage disease and normal albumin levels; higher MCM7 was found for asymptomatic patients, early stage disease, <5 involved sites, no anemia and normal albumin levels; higher CCND3 expression was found for older patients and normal lactate dehydrogenase (LDH). Univariate analysis revealed no correlation with failure-free (FFS) or overall survival (OS). Multivariate analysis revealed that high MCM7 expression was an adverse prognostic factor for OS, along with older age and advanced stage, while it was of borderline significance for FFS when adjusted for stage. These results suggest that MCM7 deserves further evaluation as a potential independent prognostic factor in larger patient series.