Cervical large cell neuroendocrine carcinoma with cytologic presentation: a case report

Large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive cervical neoplasm. Few cytologic or colposcopic findings of LCNEC have been reported. A 37-year-old woman, gravida 6, para 4, presented with vaginal bleeding for 3 months. The cervical smears showed cells dispersed as single cells...

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Bibliographic Details
Published inActa cytologica Vol. 54; no. 5 Suppl; p. 977
Main Authors Niwa, Kenji, Nonaka-Shibata, Mayuko, Satoh, Eriko, Hirose, Yoshiyuki
Format Journal Article
LanguageEnglish
Published Switzerland 01.09.2010
Subjects
Adult
Carcinoma, Large Cell - pathology
Carcinoma, Large Cell - surgery
Carcinoma, Neuroendocrine - pathology
Carcinoma, Neuroendocrine - surgery
Cell Nucleus - pathology
Cervix Uteri - pathology
Colposcopy
Fatal Outcome
Female
Humans
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - surgery
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Summary:Large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive cervical neoplasm. Few cytologic or colposcopic findings of LCNEC have been reported. A 37-year-old woman, gravida 6, para 4, presented with vaginal bleeding for 3 months. The cervical smears showed cells dispersed as single cells or arranged as loosely cohesive sheets or glandlike aggregate and the nuclear size was almost 3-5 times larger than that of small lymphocytes. The cytologic, pathologic and immunohistochemical examinations suggested LCNEC. The patient underwent a radical hysterectomy and then received radiation and systemic chemotherapy. Cytologic and colposcopic findings for LCNEC of the uterine cervix are reported. Patients with LCNEC have poor prognoses. Early diagnosis of the tumor is important.
ISSN:0001-5547