Effects of Artemisinin Dimers on Rat Breast Cancer Cells In Vitro and In Vivo

• Published in: Anticancer research Vol. 31; no. 12; pp. 4111 - 4114
• Main Authors: SINGH, Narendra P, LAI, Henry C, PARK, Ji Sun, GERHARDT, Thomas E, KIM, Byung Ju, SHUSHENG WANG, SASAKI, Tomikazu
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01.12.2011
• Subjects: Alcohols - chemistry; Animals; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antioxidants - chemistry; Artemisinins - chemistry; Artemisinins - pharmacology; Biological and medical sciences; Cell Line, Tumor; Dimerization; Female; Gynecology. Andrology. Obstetrics; Humans; In Vitro Techniques; Inhibitory Concentration 50; Mammary gland diseases; Mammary Neoplasms, Animal - drug therapy; Mammary Neoplasms, Animal - metabolism; Medical sciences; Models, Chemical; Rats; Rats, Inbred F344; Time Factors; Tumors; breast cancer cells; Breast disease; Rat; dihydroartemisinin; Rodentia; Artemisinin; Breast cancer; Malignant tumor; In vitro; Mammary gland diseases; In vivo; Vertebrata; Mammalia; Cancerology; Animal; Artemisinin dimers; Dimer; Tumor cell; Cancer
• ISSN: 0250-7005; 1791-7530

Artemisinin has been shown to be an effective antimalarial and anticancer compound. Dimers of artemisinin have been synthesized and shown to be potent antimalarials compared with monomers. In the present study, we investigated the effect of two artemisinin dimers (dimer-alcohol and dimer-hydrazone) on rat mammary adenocarcinoma cells (MTLn3) in vitro and in vivo compared with that of the artemisinin monomer dihydroartemisinin (DHA). We found that the dimers are considerably more potent than DHA in killing MTLn3 cells in vitro and suppressing the growth of MTLn3 breast tumors in vivo.