Polymorphism of DRD2 gene and ADHD

Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated...

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Bibliographic Details
Published inNeuro-endocrinology letters Vol. 27; no. 1-2; p. 236
Main Authors Serý, Omar, Drtílková, Ivana, Theiner, Pavel, Pitelová, Renáta, Staif, Radim, Znojil, Vladimír, Lochman, Jan, Didden, William
Format Journal Article
LanguageEnglish
Published Sweden 01.02.2006
Subjects
Adolescent
Alleles
Attention Deficit Disorder with Hyperactivity - epidemiology
Attention Deficit Disorder with Hyperactivity - genetics
Attention Deficit Disorder with Hyperactivity - psychology
Child
Czech Republic - epidemiology
DNA - genetics
DNA - isolation & purification
Gene Frequency
Humans
Male
Polymorphism, Genetic
Psychiatric Status Rating Scales
Receptors, Dopamine D2 - genetics
Reverse Transcriptase Polymerase Chain Reaction
Czech Republic
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Summary:Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. We found statistically different genotypic and allelic frequencies (p < 0.008, p < 0.002, respectively) of DRD2 polymorphism between two studied groups of boys. According to our results we suppose that polymorphism TaqI A of DRD2 gene is involved in the pathogenesis of childhood ADHD in male subjects. Allele A1 and genotype A1A1 in male subjects is associated with ADHD. Our study confirmed the relationship between TaqI A polymorphism of DRD2 gene and ADHD published previously.
ISSN:0172-780X