Differential expression of collagens type I and type IV in lymphangiogenesis during the angiogenic process associated with bleomycin-induced pulmonary fibrosis in rat

• Published in: Lymphology Vol. 38; no. 3; pp. 130 - 135
• Main Authors: TELES-GRILO, M. L, LEITE-ALMEIDA, H, MARTINS DOS SANTOS, J, OLIVEIRA, C, BOAVENTURA, P, GRANDE, N. R
• Format: Journal Article
• Language: English
• Published: Tucson, AZ International Society of Lymphology 01.09.2005
• Subjects: Animals; Biological and medical sciences; Bleomycin; Blood and lymphatic vessels; Cardiology. Vascular system; Collagen Type I - biosynthesis; Collagen Type IV - biosynthesis; Diabetes. Impaired glucose tolerance; Diseases of the lymphatic vessels; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Immunohistochemistry; In Situ Hybridization; Lymphangiogenesis - drug effects; Male; Management. Various non-drug treatments. Langerhans islet grafts; Medical sciences; Neovascularization, Physiologic - drug effects; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Pulmonary Fibrosis - chemically induced; Pulmonary Fibrosis - metabolism; Rats; Rats, Wistar; Thyroid. Thyroid axis (diseases); Antineoplastic agent; Lung disease; Rat; Respiratory disease; Collagen type IV; Rodentia; Cardiovascular disease; Lymphatic vessel disease; Vertebrata; Antibiotic; Mammalia; Bleomycin; Pulmonary fibrosis; Collagen type I; Glycopeptide; Animal

In order to assess the role of collagens I and IV during the angiogenic process associated with bleomycin-induced pulmonary fibrosis in rat, in situ hybridization and immunocytochemical studies were carried out. An increased expression of collagen IV was observed before an enhanced expression of col...