Differential expression of collagens type I and type IV in lymphangiogenesis during the angiogenic process associated with bleomycin-induced pulmonary fibrosis in rat

In order to assess the role of collagens I and IV during the angiogenic process associated with bleomycin-induced pulmonary fibrosis in rat, in situ hybridization and immunocytochemical studies were carried out. An increased expression of collagen IV was observed before an enhanced expression of col...

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Published inLymphology Vol. 38; no. 3; pp. 130 - 135
Main Authors TELES-GRILO, M. L, LEITE-ALMEIDA, H, MARTINS DOS SANTOS, J, OLIVEIRA, C, BOAVENTURA, P, GRANDE, N. R
Format Journal Article
LanguageEnglish
Published Tucson, AZ International Society of Lymphology 01.09.2005
Subjects
Animals
Biological and medical sciences
Bleomycin
Blood and lymphatic vessels
Cardiology. Vascular system
Collagen Type I - biosynthesis
Collagen Type IV - biosynthesis
Diabetes. Impaired glucose tolerance
Diseases of the lymphatic vessels
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Immunohistochemistry
In Situ Hybridization
Lymphangiogenesis - drug effects
Male
Management. Various non-drug treatments. Langerhans islet grafts
Medical sciences
Neovascularization, Physiologic - drug effects
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pulmonary Fibrosis - chemically induced
Pulmonary Fibrosis - metabolism
Rats
Rats, Wistar
Thyroid. Thyroid axis (diseases)
Antineoplastic agent
Lung disease
Rat
Respiratory disease
Collagen type IV
Rodentia
Cardiovascular disease
Lymphatic vessel disease
Vertebrata
Antibiotic
Mammalia
Bleomycin
Pulmonary fibrosis
Collagen type I
Glycopeptide
Animal
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Summary:In order to assess the role of collagens I and IV during the angiogenic process associated with bleomycin-induced pulmonary fibrosis in rat, in situ hybridization and immunocytochemical studies were carried out. An increased expression of collagen IV was observed before an enhanced expression of collagen I after intratracheal instillation of bleomycin. Deposits of both collagen types were detected on the 21st day after treatment with bleomycin, surrounding the new blood vessels formed during the fibrotic process. At this time, the presence of new lymphatic vessels was associated uniquely with deposition of collagen I. These observations lead us to conclude that, at least during pulmonary fibrosis, lymphangiogenesis takes place after blood angiogenesis.
ISSN:0024-7766