A positive correlation between immunohistochemical expression of CD31 and mast cell tryptase in odontogenic tumors

• Published in: Polish journal of pathology Vol. 66; no. 2; pp. 170 - 175
• Main Authors: Kouhsoltani, Maryam, Halimi, Monireh, Dibazar, Sana
• Format: Journal Article
• Language: English
• Published: Poland Termedia Publishing House 01.06.2015
• Subjects: Adult; Age; Angiogenesis; Biology; Biomarkers, Tumor - analysis; Biopsy; Cysts; Female; Growth factors; Histamine; Humans; Immunohistochemistry; Male; Mast Cells - enzymology; Mast Cells - pathology; Medical prognosis; Medical research; Microvessels - chemistry; Microvessels - pathology; Middle Aged; Neovascularization, Pathologic; Odontogenic Tumors - blood supply; Odontogenic Tumors - enzymology; Odontogenic Tumors - pathology; Platelet Endothelial Cell Adhesion Molecule-1 - analysis; Predictive Value of Tests; Prognosis; Tryptases - analysis; Tumor necrosis factor-TNF; Tumors; Young Adult
• ISSN: 1233-9687; 2084-9869
• DOI: 10.5114/pjp.2015.53014

In this study, we compared mast cell tryptase and CD31 expression between odontogenic tumors with the aim of predicting the clinical behavior of these lesions at the time of initial biopsy. We also evaluated the correlation between mast cell tryptase and CD31 expression to clarify the role of mast cells (MCs) in the growth of odontogenic tumors. Immunohistochemical staining with anti-MC tryptase and anti-CD31 antibodies was performed on 48 cases of odontogenic tumors including solid ameloblastoma (SAM), unicystic ameloblastoma (UAM), odontogenic myxoma (OM), cystic calcifying odontogenic tumor (CCOT) and adenomatoid odontogenic tumor (AOT). Ten high power fields were analyzed for each sample. Total MC count was significantly increased in SAM compared to other odontogenic tumors (p<0.05). Microvessel density was statistically higher in SAM and AOT compared to remaining odontogenic tumors (p<0.05). A significant correlation was observed between MCs and microvessels in odontogenic tumors (p=0.018, r=0.34). Our findings suggest a role for MCs in aggressive clinical behavior of odontogenic tumors. The significant correlation found between MC count and microvessel density in odontogenic tumors is in agreement with the theory of participation of MCs in tumor progression. Targeting MC activity may represent an important nonsurgical therapeutic approach, especially for aggressive odontogenic tumors.