Otoendoscopic Tympanic Repair of Tympanic Perforations Secondary to Chronic Otitis Media Using Porcine Small-intestine Membrane

• Published in: Alternative therapies in health and medicine Vol. 29; no. 3; pp. 166 - 171
• Main Authors: Li, Wenya, Zhao, Lina, Jiang, Xiuwen
• Format: Journal Article
• Language: English
• Published: United States InnoVision Health Media, Inc 01.04.2023
• Subjects: Animals; Antibiotics; Cartilage; Chronic Disease; Clinical medicine; Ear diseases; Eardrum; Endoscopy; General anesthesia; Hearing loss; Hearing Loss - complications; Hospitals; Humans; Intestine, Small; Mesentery; Microsurgery; Otitis Media - complications; Otitis Media - surgery; Otolaryngology; Otology; Patients; Retrospective Studies; Surgeons; Surgery; Surgical outcomes; Swine; Treatment Outcome; Tympanic Membrane - surgery; Tympanic Membrane Perforation - complications; Tympanic Membrane Perforation - surgery; China; Germany
• ISSN: 1078-6791

The most common cause of hearing loss is chronic otitis media. Patients often exhibit ear tightness, ear plugging, conductive hearing loss, and even secondary perforation of the tympanic membrane. Patients require antibiotics to improve symptoms, and some patients need surgical repair of the membrane. The study intended to examine the effects of two methods of surgical transplantation using porcine mesentery under an otoscope on the surgical outcomes of patients with tympanic-membrane perforation secondary to chronic otitis media, with the intent to provide a basis for clinical practice. The research team conducted a retrospective case-controlled study. The study took place at the Sir Run Run Shaw Hospital of the College of Medicine at Zhejiang University in Hangzhou, Zhejiang, China. Participants were 120 patients with tympanic membrane perforations that were secondary to chronic otitis media who had been admitted to the hospital between December 2017 and July 2019. The research team divided the participants into two groups according to the surgical indications for repair of their perforations: (1) for patients with the central type of perforations with a rich residual tympanic membrane, the surgeon used the internal implantation method, and (2) for patients with a marginal or central perforation with a low residual tympanic membrane, the surgeon used the interlayer implantation method. Both groups received the implantations under conventional microscopic tympanoplasty, and the Department of Otolaryngology Head & Neck Surgery at the hospital provided the porcine mesenteric material. The research team compared the differences between the groups in operation time, blood loss, changes in the level of hearing loss between baseline and postintervention, air-bone conductivity, treatment effects, and surgical complications. The operation time and blood loss of the internal implantation group were significantly greater than those of interlayer implantation group (P < .05). At 12 months postintervention, one participant in the internal implantation group had perforation recurrence, and two participants in the interlayer implantation group had infections and two had perforation recurrence. No significant difference existed between the groups in the complication rate (P > .05). Endoscopic repair of tympanic membrane perforations that were secondary to chronic otitis media, using porcine mesentery as the material for implantation, is a reliable treatment with few complications and good postoperative hearing recovery.